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The scientific literature contained findings of research that supported the goals and objectives of the VPI. However, to address unanswered and emerging questions relevant to informing public policy, an ongoing research program was needed. The Foundation awarded 15 research grants in an effort to inform each of the three aforementioned VPI policy goals.

Research grants were funded at: California State University, Fresno; Charles Drew University of Medicine and Science; The Marin Institute for the Prevention of Alcohol and Other Drug Problems; Prevention Research Center; Rand Corporation; Tomás Rivera Policy Institute; University of California, Davis; University of California, Los Angeles; University of California, Riverside; University of California, Santa Barbara; and the University of Southern California.